General Information of the Compound
Compound ID
CP0488217
Compound Name
2-[4-[4-[1-(benzenesulfonyl)indol-4-yl]piperazin-1-yl]butoxy]benzamide
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Structure
Formula
C29H32N4O4S
Molecular Weight
532.666
Canonical SMILES
NC(=O)c1ccccc1OCCCCN1CCN(CC1)c1cccc2n(ccc12)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C29H32N4O4S/c30-29(34)25-11-4-5-14-28(25)37-22-7-6-16-31-18-20-32(21-19-31)26-12-8-13-27-24(26)15-17-33(27)38(35,36)23-9-2-1-3-10-23/h1-5,8-15,17H,6-7,16,18-22H2,(H2,30,34)
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InChIKey
UQFXXDIPHBBVJR-UHFFFAOYSA-N
Physicochemical Property
logP
3.9584
Rotatable Bonds
10
Heavy Atom Count
38
Polar Areas
97.87
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71151757
SID: 163487638
ChEMBL ID
CHEMBL3409257
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 78 nM
   TI
   LI
   LO
   TS