General Information of the Compound
Compound ID
CP0487545
Compound Name
2-[4-[3-propanoyl-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl]piperazin-1-yl]-N-propan-2-ylacetamide
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Structure
Formula
C20H25F3N4O2S
Molecular Weight
442.507
Canonical SMILES
CCC(=O)c1csc2c(cc(nc12)N1CCN(CC(=O)NC(C)C)CC1)C(F)(F)F
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InChI
InChI=1S/C20H25F3N4O2S/c1-4-15(28)13-11-30-19-14(20(21,22)23)9-16(25-18(13)19)27-7-5-26(6-8-27)10-17(29)24-12(2)3/h9,11-12H,4-8,10H2,1-3H3,(H,24,29)
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InChIKey
NQDTXBRXKOWXML-UHFFFAOYSA-N
Physicochemical Property
logP
3.5544
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
65.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 146453400
ChEMBL ID
CHEMBL4795937
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07254, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000627 OE19 Homo sapiens (Human)  2
1
IC50 = 97 nM
   TI
   LI
   LO
   TS
2
IC50 = 120 nM
   TI
   LI
   LO
   TS