General Information of the Compound
Compound ID
CP0487210
Compound Name
[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-oxo-4-(3-phenylpropoxyamino)pyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-oxo-4-(3-phenylpropoxyamino)pyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
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Structure
Formula
C36H48N6O23P4
Molecular Weight
1056.695
Canonical SMILES
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cc\c(=N\OCCCc3ccccc3)[nH]c2=O)O[C@H]([C@@H]1O)n1cc\c(=N\OCCCc2ccccc2)[nH]c1=O
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InChI
InChI=1S/C36H48N6O23P4/c43-29-25(61-33(31(29)45)41-17-15-27(37-35(41)47)39-57-19-7-13-23-9-3-1-4-10-23)21-59-66(49,50)63-68(53,54)65-69(55,56)64-67(51,52)60-22-26-30(44)32(46)34(62-26)42-18-16-28(38-36(42)48)40-58-20-8-14-24-11-5-2-6-12-24/h1-6,9-12,15-18,25-26,29-34,43-46H,7-8,13-14,19-22H2,(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,37,39,47)(H,38,40,48)/t25-,26-,29-,30-,31-,32-,33-,34-/m1/s1
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InChIKey
QMCHGCVSODSXDQ-ZHELWVPESA-N
Physicochemical Property
logP
0.0196
Rotatable Bonds
24
Heavy Atom Count
69
Polar Areas
413.49
Hydrogen Bond Donor Count
10
Hydrogen Bond Acceptor Count
23
Complexity
69

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90656232
ChEMBL ID
CHEMBL3261380
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04714, P2Y purinoceptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT05219, P2Y purinoceptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 = 1330 nM
   TI
   LI
   LO
   TS
Protein ID: PT02796, P2Y purinoceptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS