General Information of the Compound
Compound ID
CP0475421
Compound Name
4-amino-2-butyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carbonitrile
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Structure
Formula
C19H23N5O
Molecular Weight
337.427
Canonical SMILES
CCCCc1nc2c(N)nc3cc(ccc3c2n1CC(C)(C)O)C#N
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InChI
InChI=1S/C19H23N5O/c1-4-5-6-15-23-16-17(24(15)11-19(2,3)25)13-8-7-12(10-20)9-14(13)22-18(16)21/h7-9,25H,4-6,11H2,1-3H3,(H2,21,22)
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InChIKey
JHUUOQZNDXJMSK-UHFFFAOYSA-N
Physicochemical Property
logP
3.15188
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
100.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155222093
ChEMBL ID
CHEMBL4643435
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02160, Toll-like receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
EC50 = 790 nM
   TI
   LI
   LO
   TS
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
EC50 = 3900 nM
   TI
   LI
   LO
   TS