General Information of the Compound
Compound ID
CP0474319
Compound Name
2-(2,2,3,3,3-pentafluoropropanoylamino)-N-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
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Structure
Formula
C20H16F8N2O3S
Molecular Weight
516.41
Canonical SMILES
FC(F)(F)Oc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)C(F)(F)F)sc2CCCCCc12
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InChI
InChI=1S/C20H16F8N2O3S/c21-18(22,19(23,24)25)17(32)30-16-14(10-6-2-1-3-9-13(10)34-16)15(31)29-11-7-4-5-8-12(11)33-20(26,27)28/h4-5,7-8H,1-3,6,9H2,(H,29,31)(H,30,32)
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InChIKey
XXGPMSZQAGKGKI-UHFFFAOYSA-N
Physicochemical Property
logP
6.304
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
67.43
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137634955
ChEMBL ID
CHEMBL4060277
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06716, Anoctamin-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000259 FRT Rattus norvegicus (Rat)  1
1
IC50 = 2700 nM
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