General Information of the Compound
Compound ID
CP0473566
Compound Name
3,4-dihydro-2H-quinolin-1-yl-[4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]methanone
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Structure
Formula
C26H25N5O2
Molecular Weight
439.519
Canonical SMILES
O=C(N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1)N1CCCc2ccccc12
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InChI
InChI=1S/C26H25N5O2/c32-26(31-15-5-8-19-7-2-4-10-23(19)31)30-16-13-20(14-17-30)25-28-24(29-33-25)22-12-11-18-6-1-3-9-21(18)27-22/h1-4,6-7,9-12,20H,5,8,13-17H2
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InChIKey
WVXINFMZJIIZKL-UHFFFAOYSA-N
Physicochemical Property
logP
5.037
Rotatable Bonds
2
Heavy Atom Count
33
Polar Areas
75.36
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56662176
ChEMBL ID
CHEMBL1823829
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 670 nM
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