General Information of the Compound
Compound ID
CP0473562
Compound Name
[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(methoxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
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Structure
Formula
C16H28FN3O22P4
Molecular Weight
757.293
Canonical SMILES
CONc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](F)[C@H]3O)[C@@H](O)[C@H]2O)c(=O)n1
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InChI
InChI=1S/C16H28FN3O22P4/c1-35-19-8-2-3-20(16(26)18-8)14-13(25)11(23)7(37-14)5-36-43(27,28)40-45(31,32)42-46(33,34)41-44(29,30)39-15-12(24)9(17)10(22)6(4-21)38-15/h2-3,6-7,9-15,21-25H,4-5H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,18,19,26)/t6-,7-,9+,10-,11-,12-,13-,14-,15-/m1/s1
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InChIKey
URJOBJGVBHZRMG-YIPCRTQPSA-N
Physicochemical Property
logP
-2.9025
Rotatable Bonds
15
Heavy Atom Count
46
Polar Areas
371.11
Hydrogen Bond Donor Count
10
Hydrogen Bond Acceptor Count
21
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53309529
SID: 124768878
ChEMBL ID
CHEMBL1784292
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04714, P2Y purinoceptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
Protein ID: PT05219, P2Y purinoceptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS
Protein ID: PT02796, P2Y purinoceptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
EC50 = 1440 nM
   TI
   LI
   LO
   TS