General Information of the Compound
Compound ID
CP0472389
Compound Name
5-methoxy-1-(4-methoxyphenyl)sulfonyl-3-[(4-methylpiperazin-1-yl)methyl]indole
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Structure
Formula
C22H27N3O4S
Molecular Weight
429.542
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)n1cc(CN2CCN(C)CC2)c2cc(OC)ccc12
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InChI
InChI=1S/C22H27N3O4S/c1-23-10-12-24(13-11-23)15-17-16-25(22-9-6-19(29-3)14-21(17)22)30(26,27)20-7-4-18(28-2)5-8-20/h4-9,14,16H,10-13,15H2,1-3H3
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InChIKey
MLPQPSFNIQXTNE-UHFFFAOYSA-N
Physicochemical Property
logP
2.6429
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
64.01
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10094169
SID: 15081499
ChEMBL ID
CHEMBL4070850
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 18.3 nM
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