General Information of the Compound
Compound ID
CP0470592
Compound Name
(E)-3-(3-hydroxyphenyl)-N-[3-[[(E)-3-(3-hydroxyphenyl)prop-2-enoyl]amino]propyl]prop-2-enamide
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Structure
Formula
C21H22N2O4
Molecular Weight
366.417
Canonical SMILES
Oc1cccc(\C=C\C(=O)NCCCNC(=O)\C=C\c2cccc(O)c2)c1
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InChI
InChI=1S/C21H22N2O4/c24-18-6-1-4-16(14-18)8-10-20(26)22-12-3-13-23-21(27)11-9-17-5-2-7-19(25)15-17/h1-2,4-11,14-15,24-25H,3,12-13H2,(H,22,26)(H,23,27)/b10-8+,11-9+
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InChIKey
DBNMGNOATQUFKE-GFULKKFKSA-N
Physicochemical Property
logP
2.4469
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
98.66
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90646955
ChEMBL ID
CHEMBL4450699
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05154, Tyrosinase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000396 B16-F1 Mus musculus (Mouse)  1
1
IC50 = 40200 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000396 B16-F1 Mus musculus (Mouse)  1
1
IC50 = 95300 nM
   TI
   LI
   LO
   TS