General Information of the Compound
Compound ID
CP0469403
Compound Name
3-(3-chloro-1H-pyrazol-5-yl)-1,2-dihydroquinoxalin-2-one
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Synonyms
3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one
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Structure
Formula
C11H7ClN4O
Molecular Weight
246.657
Canonical SMILES
Clc1cc(n[nH]1)-c1nc2ccccc2[nH]c1=O
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InChI
InChI=1S/C11H7ClN4O/c12-9-5-8(15-16-9)10-11(17)14-7-4-2-1-3-6(7)13-10/h1-5H,(H,14,17)(H,15,16)
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InChIKey
HKRYFPDYIBYUGZ-UHFFFAOYSA-N
Physicochemical Property
logP
1.9666
Rotatable Bonds
1
Heavy Atom Count
17
Polar Areas
74.43
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
17

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135407706
SID: 16216917
ChEMBL ID
CHEMBL403521
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3336 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 125 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one )
Drug Name 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one
Target(s)
Adenosine A3 receptor (ADORA3)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor