General Information of the Compound
Compound ID
CP0469361
Compound Name
N-[1-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]tetrazol-5-yl]acetamide;dihydrochloride
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Structure
Formula
C22H29Cl2N7O2
Molecular Weight
494.427
Canonical SMILES
Cl.Cl.COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)-n1nnnc1NC(C)=O
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InChI
InChI=1S/C22H27N7O2.2ClH/c1-15(30)25-22-26-27-28-29(22)18-10-11-20(31-2)17(13-18)14-24-19-9-6-12-23-21(19)16-7-4-3-5-8-16;;/h3-5,7-8,10-11,13,19,21,23-24H,6,9,12,14H2,1-2H3,(H,25,26,28,30);2*1H/t19-,21-;;/m0../s1
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InChIKey
LQSYCABKISDSLJ-ANXDEKAJSA-N
Physicochemical Property
logP
3.0558
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
105.99
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18667231
ChEMBL ID
CHEMBL556981
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.2512 nM
   TI
   LI
   LO
   TS