General Information of the Compound
Compound ID
CP0468192
Compound Name
US8901315, 21
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Structure
Formula
C24H28N4O2S
Molecular Weight
436.581
Canonical SMILES
CCC(=O)N1CCc2cc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)ccc12
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InChI
InChI=1S/C24H28N4O2S/c1-3-22(29)27-12-11-16-13-17(9-10-20(16)27)25-23(30)21-14-19-15(2)26-28(24(19)31-21)18-7-5-4-6-8-18/h9-10,13-14,18H,3-8,11-12H2,1-2H3,(H,25,30)
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InChIKey
KGOVXGBUAYNUMR-UHFFFAOYSA-N
Physicochemical Property
logP
5.46282
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
67.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57698023
ChEMBL ID
CHEMBL3647456
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01728, High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  1
1
IC50 = 84 nM
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