General Information of the Compound
Compound ID
CP0467687
Compound Name
8-[2-[4-(3,4-dichlorophenyl)-1-(furan-2-carbonyl)piperidin-4-yl]oxyethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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Structure
Formula
C31H34Cl2N4O4
Molecular Weight
597.543
Canonical SMILES
Clc1ccc(cc1Cl)C1(CCN(CC1)C(=O)c1ccco1)OCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
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InChI
InChI=1S/C31H34Cl2N4O4/c32-25-9-8-23(21-26(25)33)31(12-16-36(17-13-31)28(38)27-7-4-19-40-27)41-20-18-35-14-10-30(11-15-35)29(39)34-22-37(30)24-5-2-1-3-6-24/h1-9,19,21H,10-18,20,22H2,(H,34,39)
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InChIKey
FVVHYUGPXSRXAE-UHFFFAOYSA-N
Physicochemical Property
logP
5.163
Rotatable Bonds
7
Heavy Atom Count
41
Polar Areas
78.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25130569
SID: 56454932
ChEMBL ID
CHEMBL500523
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3467.37 nM
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