General Information of the Compound
Compound ID
CP0466904
Compound Name
6-N-cyclooctyl-2-N-phenyl-7H-purine-2,6-diamine
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Synonyms
CHEMBL365026
N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine
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Structure
Formula
C19H24N6
Molecular Weight
336.443
Canonical SMILES
C1CCCC(CCC1)Nc1nc(Nc2ccccc2)nc2nc[nH]c12
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InChI
InChI=1S/C19H24N6/c1-2-5-9-14(10-6-3-1)22-18-16-17(21-13-20-16)24-19(25-18)23-15-11-7-4-8-12-15/h4,7-8,11-14H,1-3,5-6,9-10H2,(H3,20,21,22,23,24,25)
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InChIKey
MSEVQUIRSAPIPS-UHFFFAOYSA-N
Physicochemical Property
logP
4.6213
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
78.52
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11484484
SID: 16586030
ChEMBL ID
CHEMBL365026
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4470 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 46000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 340 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine )
Drug Name N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine
Target(s)
Adenosine A3 receptor (ADORA3)
Inhibitor
Adenosine A1 receptor (ADORA1)
Inhibitor