General Information of the Compound
Compound ID
CP0466652
Compound Name
US8901315, 423
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Formula
C24H36N4O3S
Molecular Weight
460.644
Canonical SMILES
Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCC(CO)CC1
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InChI
InChI=1S/C24H36N4O3S/c1-16-21-14-22(32-24(21)28(26-16)20-8-12-31-13-9-20)23(30)25-18-2-4-19(5-3-18)27-10-6-17(15-29)7-11-27/h14,17-20,29H,2-13,15H2,1H3,(H,25,30)/t18-,19-
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InChIKey
BLOOHCCBHCWMJP-WGSAOQKQSA-N
Physicochemical Property
logP
3.50302
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
79.62
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3650341
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01728, High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  1
1
IC50 = 72 nM
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