General Information of the Compound
Compound ID
CP0465486
Compound Name
US8618114, 1.2.12(3)
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Structure
Formula
C18H24N6O2S
Molecular Weight
388.497
Canonical SMILES
CNc1nn2c(NCCN(C)C)cc(C)nc2c1S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C18H24N6O2S/c1-13-12-15(20-10-11-23(3)4)24-18(21-13)16(17(19-2)22-24)27(25,26)14-8-6-5-7-9-14/h5-9,12,20H,10-11H2,1-4H3,(H,19,22)
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InChIKey
FHAIKHWOGVRZCX-UHFFFAOYSA-N
Physicochemical Property
logP
1.88572
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
91.63
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56849580
SID: 135381343
ChEMBL ID
CHEMBL1922620
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 1549 nM
   TI
   LI
   LO
   TS
2
Ki = 69.18 nM
   TI
   LI
   LO
   TS