General Information of the Compound
Compound ID
CP0462313
Compound Name
17beta-Hydroxy-11beta-{4-[5-(1,3-dioxol-2-yl)-N-methylpentylamino]-phenyl}-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C36H47NO4
Molecular Weight
557.775
Canonical SMILES
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCC1OCCO1
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InChI
InChI=1S/C36H47NO4/c1-4-18-36(39)19-17-32-30-15-11-26-23-28(38)14-16-29(26)34(30)31(24-35(32,36)2)25-9-12-27(13-10-25)37(3)20-7-5-6-8-33-40-21-22-41-33/h9-10,12-13,23,30-33,39H,5-8,11,14-17,19-22,24H2,1-3H3/t30-,31+,32-,35-,36-/m0/s1
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InChIKey
RXBCIQKTFIEBFN-ONBGVYQJSA-N
Physicochemical Property
logP
6.71
Rotatable Bonds
8
Heavy Atom Count
41
Polar Areas
59
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231473
SID: 57583402
ChEMBL ID
CHEMBL507253
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 0.17 nM
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