General Information of the Compound
Compound ID
CP0460132
Compound Name
1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-8-[2-[3-(3,4-dimethoxyphenyl)-4-oxoimidazolidin-1-yl]acetyl]-3-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
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Structure
Formula
C30H31F6N5O6
Molecular Weight
671.595
Canonical SMILES
COc1ccc(cc1OC)N1CN(CC(=O)N2CCC3(CC2)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)N(C)C3=O)CC1=O
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InChI
InChI=1S/C30H31F6N5O6/c1-37-26(44)28(41(27(37)45)14-18-10-19(29(31,32)33)12-20(11-18)30(34,35)36)6-8-39(9-7-28)24(42)15-38-16-25(43)40(17-38)21-4-5-22(46-2)23(13-21)47-3/h4-5,10-13H,6-9,14-17H2,1-3H3
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InChIKey
LLDXCQQWICNMIB-UHFFFAOYSA-N
Physicochemical Property
logP
3.8029
Rotatable Bonds
7
Heavy Atom Count
47
Polar Areas
102.94
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44318865
ChEMBL ID
CHEMBL86053
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1698.24 nM
   TI
   LI
   LO
   TS