General Information of the Compound
Compound ID
CP0459974
Compound Name
N-[(4-ethylmorpholin-3-yl)methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
    Show/Hide
Structure
Formula
C24H30N6O3
Molecular Weight
450.543
Canonical SMILES
CCN1CCOCC1CNC(=O)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
    Show/Hide
InChI
InChI=1S/C24H30N6O3/c1-2-29-13-14-32-16-19(29)15-25-24(31)30-11-9-18(10-12-30)23-27-22(28-33-23)21-8-7-17-5-3-4-6-20(17)26-21/h3-8,18-19H,2,9-16H2,1H3,(H,25,31)
    Show/Hide
InChIKey
YEGOYQRGLZXUDF-UHFFFAOYSA-N
Physicochemical Property
logP
2.8945
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
96.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 56671927
ChEMBL ID
CHEMBL1822460
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
2
IC50 = 390 nM
   TI
   LI
   LO
   TS