General Information of the Compound
Compound ID
CP0459002
Compound Name
N-[4-[(1S,2R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-5-oxo-2,3,8,8a-tetrahydro-1H-indolizin-7-yl]phenyl]methanesulfonamide
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Structure
Formula
C31H27F7N2O4S
Molecular Weight
656.62
Canonical SMILES
C[C@@H](O[C@H]1CN2C(CC(=CC2=O)c2ccc(NS(C)(=O)=O)cc2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C31H27F7N2O4S/c1-17(20-11-22(30(33,34)35)15-23(12-20)31(36,37)38)44-27-16-40-26(29(27)19-3-7-24(32)8-4-19)13-21(14-28(40)41)18-5-9-25(10-6-18)39-45(2,42)43/h3-12,14-15,17,26-27,29,39H,13,16H2,1-2H3/t17-,26?,27+,29+/m1/s1
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InChIKey
WDALRJNIULBPSY-QGYSTOEISA-N
Physicochemical Property
logP
7.1629
Rotatable Bonds
7
Heavy Atom Count
45
Polar Areas
75.71
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24889111
SID: 51081610
ChEMBL ID
CHEMBL1090287
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 54 nM
   TI
   LI
   LO
   TS