General Information of the Compound
Compound ID
CP0458869
Compound Name
(4aS,8aR)-4-(3,4-dimethoxyphenyl)-2-[[4-[(4-oxopiperidin-1-yl)methyl]phenyl]methyl]-4a,5,8,8a-tetrahydrophthalazin-1-one
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Structure
Formula
C29H33N3O4
Molecular Weight
487.6
Canonical SMILES
COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCC(=O)CC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12
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InChI
InChI=1S/C29H33N3O4/c1-35-26-12-11-22(17-27(26)36-2)28-24-5-3-4-6-25(24)29(34)32(30-28)19-21-9-7-20(8-10-21)18-31-15-13-23(33)14-16-31/h3-4,7-12,17,24-25H,5-6,13-16,18-19H2,1-2H3/t24-,25+/m0/s1
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InChIKey
ZQJQVLFFFPAOBV-LOSJGSFVSA-N
Physicochemical Property
logP
4.1976
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
71.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 12000858
SID: 17500115
ChEMBL ID
CHEMBL595064
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01538, 3',5'-cyclic-AMP phosphodiesterase 4D
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 0.9 nM
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