General Information of the Compound
Compound ID
CP0458868
Compound Name
5-(2-Chloro-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid
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Structure
Formula
C22H26ClN9O4
Molecular Weight
515.962
Canonical SMILES
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCCNC(=O)CCl)C(O)=O
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InChI
InChI=1S/C22H26ClN9O4/c1-32(11-13-10-27-19-17(28-13)18(24)30-22(25)31-19)14-6-4-12(5-7-14)20(34)29-15(21(35)36)3-2-8-26-16(33)9-23/h4-7,10,15H,2-3,8-9,11H2,1H3,(H,26,33)(H,29,34)(H,35,36)(H4,24,25,27,30,31)
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InChIKey
DYKMAWUJPLYJRO-UHFFFAOYSA-N
Physicochemical Property
logP
0.5388
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
202.34
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
10
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 13844639
ChEMBL ID
CHEMBL35312
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02055, Dihydrofolate reductase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000343 L1210/R81 Mus musculus (Mouse)  1
1
IC50 = 32 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  1
1
IC50 = 105 nM
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   TS