General Information of the Compound
Compound ID
CP0458669
Compound Name
1-{[(5R,8R,11S)-5-[(3-chlorophenyl)methyl]-6,9,12-trioxo-8-(propan-2-yl)-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-1,4,7,10,13-benzoxatetrazacyclooctadecin-11-yl]methyl}guanidine
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Structure
Formula
C29H40ClN7O4
Molecular Weight
586.137
Canonical SMILES
CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN=C(N)N)NC1=O
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InChI
InChI=1S/C29H40ClN7O4/c1-18(2)25-28(40)36-23(17-35-29(31)32)26(38)34-12-6-9-20-8-3-4-11-24(20)41-14-13-33-22(27(39)37-25)16-19-7-5-10-21(30)15-19/h3-5,7-8,10-11,15,18,22-23,25,33H,6,9,12-14,16-17H2,1-2H3,(H,34,38)(H,36,40)(H,37,39)(H4,31,32,35)/t22-,23+,25-/m1/s1
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InChIKey
SVAAEIIODLRBGT-GIFXNVAJSA-N
Physicochemical Property
logP
0.8811
Rotatable Bonds
5
Heavy Atom Count
41
Polar Areas
172.96
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
6
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44432980
ChEMBL ID
CHEMBL392553
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01121, Motilin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 57 nM
   TI
   LI
   LO
   TS