General Information of the Compound
Compound ID
CP0457808
Compound Name
CHEMBL4248488
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Formula
C23H22F3N3O2S
Molecular Weight
461.509
Canonical SMILES
FC(F)(F)c1ccc(N[C@H]2CC[C@@H](CC2)S(=O)(=O)c2ccc(cc2)-c2cccnc2)nc1
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InChI
InChI=1S/C23H22F3N3O2S/c24-23(25,26)18-5-12-22(28-15-18)29-19-6-10-21(11-7-19)32(30,31)20-8-3-16(4-9-20)17-2-1-13-27-14-17/h1-5,8-9,12-15,19,21H,6-7,10-11H2,(H,28,29)/t19-,21-
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InChIKey
KDEOQIRBKNZGKN-XUTJKUGGSA-N
Physicochemical Property
logP
5.3594
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
71.95
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4248488
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03815, C-C chemokine receptor type 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 48 nM
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