General Information of the Compound
Compound ID
CP0456464
Compound Name
(S)-5-(((1R,2S,3S)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentylamino)methyl)pyrrolidin-2-one
    Show/Hide
Structure
Formula
C26H27F7N2O2
Molecular Weight
532.5
Canonical SMILES
C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
    Show/Hide
InChI
InChI=1S/C26H27F7N2O2/c1-14(16-10-17(25(28,29)30)12-18(11-16)26(31,32)33)37-22-8-7-21(34-13-20-6-9-23(36)35-20)24(22)15-2-4-19(27)5-3-15/h2-5,10-12,14,20-22,24,34H,6-9,13H2,1H3,(H,35,36)/t14-,20+,21-,22+,24+/m1/s1
    Show/Hide
InChIKey
TTYKBSXKWCQPFQ-OCGBXCADSA-N
Physicochemical Property
logP
6.1239
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
50.36
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 22885696
ChEMBL ID
CHEMBL378416
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.34 nM
   TI
   LI
   LO
   TS