General Information of the Compound
Compound ID
CP0456175
Compound Name
N-[4-(2,2-difluoro-4,6,10,12-tetramethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)butyl]-2-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)phenoxy]acetamide
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Structure
Formula
C33H38BF2N7O4
Molecular Weight
645.52
Canonical SMILES
CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1ccc(OCC(=O)NCCCCC2=C3C(C)=CC(C)=[N+]3[B-](F)(F)n3c(C)cc(C)c23)cc1
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InChI
InChI=1S/C33H38BF2N7O4/c1-6-15-41-32(45)27-31(40-33(41)46)39-30(38-27)23-10-12-24(13-11-23)47-18-26(44)37-14-8-7-9-25-28-19(2)16-21(4)42(28)34(35,36)43-22(5)17-20(3)29(25)43/h10-13,16-17H,6-9,14-15,18H2,1-5H3,(H,37,44)(H,38,39)(H,40,46)
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InChIKey
SSMBHKCARNXPJQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.65444
Rotatable Bonds
11
Heavy Atom Count
47
Polar Areas
129.81
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145975418
ChEMBL ID
CHEMBL4206556
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 719 nM
   TI
   LI
   LO
   TS