General Information of the Compound
Compound ID
CP0456121
Compound Name
2-[6-amino-3,5-dicyano-4-[4-(2-methylpropoxy)phenyl]pyridin-2-yl]sulfanylacetamide
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Structure
Formula
C19H19N5O2S
Molecular Weight
381.461
Canonical SMILES
CC(C)COc1ccc(cc1)-c1c(C#N)c(N)nc(SCC(N)=O)c1C#N
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InChI
InChI=1S/C19H19N5O2S/c1-11(2)9-26-13-5-3-12(4-6-13)17-14(7-20)18(23)24-19(15(17)8-21)27-10-16(22)25/h3-6,11H,9-10H2,1-2H3,(H2,22,25)(H2,23,24)
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InChIKey
RXIAEMUBUHXFFR-UHFFFAOYSA-N
Physicochemical Property
logP
2.68636
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
138.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 143294251
ChEMBL ID
CHEMBL4215145
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 603 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 307 nM
   TI
   LI
   LO
   TS