General Information of the Compound
Compound ID
CP0455840
Compound Name
8-hydroxy-5-[1-hydroxy-2-[3-(2-methoxyphenyl)propylamino]ethyl]-1H-quinolin-2-one
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Structure
Formula
C21H24N2O4
Molecular Weight
368.433
Canonical SMILES
COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12
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InChI
InChI=1S/C21H24N2O4/c1-27-19-7-3-2-5-14(19)6-4-12-22-13-18(25)15-8-10-17(24)21-16(15)9-11-20(26)23-21/h2-3,5,7-11,18,22,24-25H,4,6,12-13H2,1H3,(H,23,26)
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InChIKey
NIUAMIBWLXADAK-UHFFFAOYSA-N
Physicochemical Property
logP
2.4981
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
94.58
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155536813
ChEMBL ID
CHEMBL4473790
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01179, Beta-1 adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 11.22 nM
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   LI
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   TS
Protein ID: PT01494, Beta-2 adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 0.04266 nM
   TI
   LI
   LO
   TS