General Information of the Compound
Compound ID
CP0455332
Compound Name
2-[1-(2,4-Difluoro-benzenesulfonyl)-1H-indol-6-yl]-octahydro-pyrido[1,2-a]pyrazine
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Structure
Formula
C22H23F2N3O2S
Molecular Weight
431.508
Canonical SMILES
Fc1ccc(c(F)c1)S(=O)(=O)n1ccc2ccc(cc12)N1CCN2CCCCC2C1
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InChI
InChI=1S/C22H23F2N3O2S/c23-17-5-7-22(20(24)13-17)30(28,29)27-10-8-16-4-6-18(14-21(16)27)26-12-11-25-9-2-1-3-19(25)15-26/h4-8,10,13-14,19H,1-3,9,11-12,15H2
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InChIKey
NTWYASUGXMSTLR-UHFFFAOYSA-N
Physicochemical Property
logP
3.831
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
45.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44293077
ChEMBL ID
CHEMBL49598
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3.6 nM
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