General Information of the Compound
Compound ID
CP0454528
Compound Name
5-(Dimethylamino)-N-(3-{4-[6-({[5-(dimethylamino)-1-naphthyl]-sulfonyl}amino)hexyl]piperazin-1-yl}-4-methoxyphenyl)naphthalene-1-sulfonamide
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Structure
Formula
C41H52N6O5S2
Molecular Weight
773.038
Canonical SMILES
COc1ccc(NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1N1CCN(CCCCCCNS(=O)(=O)c2cccc3c(cccc23)N(C)C)CC1
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InChI
InChI=1S/C41H52N6O5S2/c1-44(2)36-18-10-16-34-32(36)14-12-20-40(34)53(48,49)42-24-8-6-7-9-25-46-26-28-47(29-27-46)38-30-31(22-23-39(38)52-5)43-54(50,51)41-21-13-15-33-35(41)17-11-19-37(33)45(3)4/h10-23,30,42-43H,6-9,24-29H2,1-5H3
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InChIKey
XMJHQAKLGNJANW-UHFFFAOYSA-N
Physicochemical Property
logP
6.5953
Rotatable Bonds
16
Heavy Atom Count
54
Polar Areas
114.53
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49781254
SID: 103055546
ChEMBL ID
CHEMBL1256258
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 554 nM
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