General Information of the Compound
Compound ID
CP0454463
Compound Name
(2R,3S,4R,5R)-2-[(3,5-dimethylpyrazol-1-yl)methyl]-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol
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Structure
Formula
C19H25N7O4
Molecular Weight
415.454
Canonical SMILES
Cc1cc(C)n(C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N[C@@H]4CCOC4)ncnc23)n1
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InChI
InChI=1S/C19H25N7O4/c1-10-5-11(2)26(24-10)6-13-15(27)16(28)19(30-13)25-9-22-14-17(20-8-21-18(14)25)23-12-3-4-29-7-12/h5,8-9,12-13,15-16,19,27-28H,3-4,6-7H2,1-2H3,(H,20,21,23)/t12-,13-,15-,16-,19-/m1/s1
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InChIKey
GGKFOSNIHINDFM-BYMDKACISA-N
Physicochemical Property
logP
0.15984
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
132.37
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
11
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137656139
ChEMBL ID
CHEMBL4094884
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 491 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 28600 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 60000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5280 nM
   TI
   LI
   LO
   TS