General Information of the Compound
Compound ID
CP0453949
Compound Name
1-[2-[(3,5-ditert-butylphenyl)methoxy]-1-phenylethyl]piperazine
    Show/Hide
Structure
Formula
C27H40N2O
Molecular Weight
408.63
Canonical SMILES
CC(C)(C)c1cc(COCC(N2CCNCC2)c2ccccc2)cc(c1)C(C)(C)C
    Show/Hide
InChI
InChI=1S/C27H40N2O/c1-26(2,3)23-16-21(17-24(18-23)27(4,5)6)19-30-20-25(22-10-8-7-9-11-22)29-14-12-28-13-15-29/h7-11,16-18,25,28H,12-15,19-20H2,1-6H3
    Show/Hide
InChIKey
SKFQAUXRVOPVSQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.4447
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
24.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44338531
ChEMBL ID
CHEMBL111304
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
2
Ki = 100 nM
   TI
   LI
   LO
   TS