General Information of the Compound
Compound ID
CP0453426
Compound Name
ethyl 6-benzamido-2-propan-2-ylpyrazolo[3,4-d]pyrimidine-4-carboxylate
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Structure
Formula
C18H19N5O3
Molecular Weight
353.382
Canonical SMILES
CCOC(=O)c1nc(NC(=O)c2ccccc2)nc2nn(cc12)C(C)C
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InChI
InChI=1S/C18H19N5O3/c1-4-26-17(25)14-13-10-23(11(2)3)22-15(13)20-18(19-14)21-16(24)12-8-6-5-7-9-12/h5-11H,4H2,1-3H3,(H,20,21,22,24)
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InChIKey
GLPSECISKLWDKC-UHFFFAOYSA-N
Physicochemical Property
logP
2.8362
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118732290
ChEMBL ID
CHEMBL3410306
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4300 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3300 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8600 nM
   TI
   LI
   LO
   TS