General Information of the Compound
Compound ID
CP0453366
Compound Name
1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[2-(4-chloro-phenyl)-5-furan-2-yl-1-methyl-1H-indol-3-yl]-propan-1-one
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Structure
Formula
C34H33ClN2O3
Molecular Weight
553.102
Canonical SMILES
Cn1c(c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(ccc12)-c1ccco1)-c1ccc(Cl)cc1
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InChI
InChI=1S/C34H33ClN2O3/c1-36-30-15-11-26(31-8-5-21-40-31)22-29(30)28(33(36)25-9-12-27(35)13-10-25)14-16-32(38)37-19-17-34(39,18-20-37)23-24-6-3-2-4-7-24/h2-13,15,21-22,39H,14,16-20,23H2,1H3
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InChIKey
VPVCVDNSGSGCQY-UHFFFAOYSA-N
Physicochemical Property
logP
7.2875
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
58.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44274180
ChEMBL ID
CHEMBL418186
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.79 nM
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