General Information of the Compound
Compound ID
CP0452543
Compound Name
3-[[7-[3-(1,4-diazepan-1-yl)propoxy]-6-methoxyquinazolin-4-yl]amino]-4-fluoro-2-methylphenol
    Show/Hide
Structure
Formula
C24H30FN5O3
Molecular Weight
455.534
Canonical SMILES
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCNCC1
    Show/Hide
InChI
InChI=1S/C24H30FN5O3/c1-16-20(31)6-5-18(25)23(16)29-24-17-13-21(32-2)22(14-19(17)27-15-28-24)33-12-4-10-30-9-3-7-26-8-11-30/h5-6,13-15,26,31H,3-4,7-12H2,1-2H3,(H,27,28,29)
    Show/Hide
InChIKey
NTDCKDIQTMHRAC-UHFFFAOYSA-N
Physicochemical Property
logP
3.59932
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
91.77
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 127046976
ChEMBL ID
CHEMBL3799971
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS