General Information of the Compound
Compound ID
CP0452353
Compound Name
N-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C22H22N6O3
Molecular Weight
418.457
Canonical SMILES
Cc1noc(C)c1NC(=O)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C22H22N6O3/c1-13-19(14(2)30-26-13)24-22(29)28-11-9-16(10-12-28)21-25-20(27-31-21)18-8-7-15-5-3-4-6-17(15)23-18/h3-8,16H,9-12H2,1-2H3,(H,24,29)
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InChIKey
USEMHKXTQIXFLM-UHFFFAOYSA-N
Physicochemical Property
logP
4.30114
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
110.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56675926
ChEMBL ID
CHEMBL1823838
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 1500 nM
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