General Information of the Compound
Compound ID
CP0451727
Compound Name
N-[[4-[4-[4-[1-(benzenesulfonyl)indol-4-yl]piperazin-1-yl]butoxy]phenyl]methyl]-N-methylprop-2-yn-1-amine
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Formula
C33H38N4O3S
Molecular Weight
570.759
Canonical SMILES
CN(CC#C)Cc1ccc(OCCCCN2CCN(CC2)c2cccc3n(ccc23)S(=O)(=O)c2ccccc2)cc1
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InChI
InChI=1S/C33H38N4O3S/c1-3-19-34(2)27-28-14-16-29(17-15-28)40-26-8-7-20-35-22-24-36(25-23-35)32-12-9-13-33-31(32)18-21-37(33)41(38,39)30-10-5-4-6-11-30/h1,4-6,9-18,21H,7-8,19-20,22-27H2,2H3
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InChIKey
UGLRAHNKSOSORS-UHFFFAOYSA-N
Physicochemical Property
logP
4.9245
Rotatable Bonds
12
Heavy Atom Count
41
Polar Areas
58.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4761469
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 54 nM
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