General Information of the Compound
Compound ID
CP0451327
Compound Name
N-[10-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]decyl]bicyclo[2.2.2]octa-2,5-diene-2-carboxamide
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Formula
C29H42N6O5
Molecular Weight
554.692
Canonical SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCCCCCCCCCNC(=O)C3=CC4CCC3C=C4)ncnc12
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InChI
InChI=1S/C29H42N6O5/c36-16-22-24(37)25(38)29(40-22)35-18-34-23-26(32-17-33-27(23)35)30-13-7-5-3-1-2-4-6-8-14-31-28(39)21-15-19-9-11-20(21)12-10-19/h9,11,15,17-20,22,24-25,29,36-38H,1-8,10,12-14,16H2,(H,31,39)(H,30,32,33)/t19?,20?,22-,24-,25-,29-/m1/s1
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InChIKey
DHIPETZJOKCSCR-MUKWLTJGSA-N
Physicochemical Property
logP
2.6091
Rotatable Bonds
15
Heavy Atom Count
40
Polar Areas
154.65
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
10
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4754372
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000386 Flp-In-CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 25.12 nM
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