General Information of the Compound
Compound ID
CP0450801
Compound Name
US8952150, 124
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Structure
Formula
C37H40N8O5
Molecular Weight
676.778
Canonical SMILES
CN(c1ccc(cc1)C(=O)NCc1ccccc1)c1nc(NCCOCCOCCNC(=O)c2ccccc2)nc(Nc2ccc(O)cc2)n1
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InChI
InChI=1S/C37H40N8O5/c1-45(31-16-12-29(13-17-31)34(48)40-26-27-8-4-2-5-9-27)37-43-35(42-36(44-37)41-30-14-18-32(46)19-15-30)39-21-23-50-25-24-49-22-20-38-33(47)28-10-6-3-7-11-28/h2-19,46H,20-26H2,1H3,(H,38,47)(H,40,48)(H2,39,41,42,43,44)
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InChIKey
CNMXGJVQBLWDOU-UHFFFAOYSA-N
Physicochemical Property
logP
4.8938
Rotatable Bonds
18
Heavy Atom Count
50
Polar Areas
162.86
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
11
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68394743
ChEMBL ID
CHEMBL3650480
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06205, Solute carrier organic anion transporter family member 2A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000031 MDCK Canis lupus familiaris (Dog)  1
1
IC50 = 34 nM
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