General Information of the Compound
Compound ID
CP0449307
Compound Name
9-(4,5-dimethylfuran-2-yl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione
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Structure
Formula
C27H24N4O3
Molecular Weight
452.514
Canonical SMILES
Cc1cc(oc1C)C1Nc2ccccc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1
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InChI
InChI=1S/C27H24N4O3/c1-15-14-20(34-16(15)2)22-25-24-21(26(32)30(4)27(33)29(24)3)23(17-10-6-5-7-11-17)31(25)19-13-9-8-12-18(19)28-22/h5-14,22,28H,1-4H3
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InChIKey
BVOYIPGLBAGFQD-UHFFFAOYSA-N
Physicochemical Property
logP
4.41964
Rotatable Bonds
2
Heavy Atom Count
34
Polar Areas
74.1
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53392871
SID: 125321178
ChEMBL ID
CHEMBL1831056
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02042, Cystic fibrosis transmembrane conductance regulator
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000259 FRT Rattus norvegicus (Rat)  1
1
IC50 = 1700 nM
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   LI
   LO
   TS