General Information of the Compound
Compound ID
CP0446154
Compound Name
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-(methoxyamino)-2-[2-(4-pentylphenyl)ethynyl]purin-9-yl]oxolane-2-carboxamide
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Structure
Formula
C26H32N6O5
Molecular Weight
508.579
Canonical SMILES
CCCCCc1ccc(cc1)C#Cc1nc(NOC)c2ncn([C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(=O)NCC)c2n1
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InChI
InChI=1S/C26H32N6O5/c1-4-6-7-8-16-9-11-17(12-10-16)13-14-18-29-23(31-36-3)19-24(30-18)32(15-28-19)26-21(34)20(33)22(37-26)25(35)27-5-2/h9-12,15,20-22,26,33-34H,4-8H2,1-3H3,(H,27,35)(H,29,30,31)/t20-,21+,22-,26+/m0/s1
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InChIKey
QNYOBYKULUANIU-IMIIHFCZSA-N
Physicochemical Property
logP
1.6874
Rotatable Bonds
9
Heavy Atom Count
37
Polar Areas
143.65
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16115907
SID: 24762993
ChEMBL ID
CHEMBL374336
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4090 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 27100 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 68 nM
   TI
   LI
   LO
   TS