General Information of the Compound
Compound ID
CP0445031
Compound Name
1-acetyl-N-(3-chloro-4-methylphenyl)-N-[3-[2-methyl-4-[(4-methylphenyl)methyl]piperazin-1-yl]propyl]piperidine-4-carboxamide
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Structure
Formula
C31H43ClN4O2
Molecular Weight
539.164
Canonical SMILES
CC1CN(Cc2ccc(C)cc2)CCN1CCCN(C(=O)C1CCN(CC1)C(C)=O)c1ccc(C)c(Cl)c1
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InChI
InChI=1S/C31H43ClN4O2/c1-23-6-9-27(10-7-23)22-33-18-19-34(25(3)21-33)14-5-15-36(29-11-8-24(2)30(32)20-29)31(38)28-12-16-35(17-13-28)26(4)37/h6-11,20,25,28H,5,12-19,21-22H2,1-4H3
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InChIKey
DEYKOEXQQNSWIG-UHFFFAOYSA-N
Physicochemical Property
logP
5.14474
Rotatable Bonds
8
Heavy Atom Count
38
Polar Areas
47.1
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118727173
ChEMBL ID
CHEMBL3397984
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 25.1 nM
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