General Information of the Compound
Compound ID
CP0443750
Compound Name
3-chloro-4-[(4-methylpiperazin-1-yl)methyl]-1-naphthalen-1-ylsulfonylindole
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Structure
Formula
C24H24ClN3O2S
Molecular Weight
453.995
Canonical SMILES
CN1CCN(Cc2cccc3n(cc(Cl)c23)S(=O)(=O)c2cccc3ccccc23)CC1
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InChI
InChI=1S/C24H24ClN3O2S/c1-26-12-14-27(15-13-26)16-19-8-4-10-22-24(19)21(25)17-28(22)31(29,30)23-11-5-7-18-6-2-3-9-20(18)23/h2-11,17H,12-16H2,1H3
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InChIKey
SMEPDBUGUBZRQN-UHFFFAOYSA-N
Physicochemical Property
logP
4.4323
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
45.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24967097
SID: 56265238
ChEMBL ID
CHEMBL2207379
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 165 nM
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