General Information of the Compound
Compound ID
CP0443489
Compound Name
1-[3-(N-(1-acetylpiperidine-4-carbonyl)-3-chloroanilino)propyl]-N-ethyl-N-[(4-methylphenyl)methyl]piperidine-4-carboxamide
    Show/Hide
Structure
Formula
C33H45ClN4O3
Molecular Weight
581.201
Canonical SMILES
CCN(Cc1ccc(C)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(CC2)C(C)=O)c2cccc(Cl)c2)CC1
    Show/Hide
InChI
InChI=1S/C33H45ClN4O3/c1-4-36(24-27-11-9-25(2)10-12-27)32(40)28-13-19-35(20-14-28)17-6-18-38(31-8-5-7-30(34)23-31)33(41)29-15-21-37(22-16-29)26(3)39/h5,7-12,23,28-29H,4,6,13-22,24H2,1-3H3
    Show/Hide
InChIKey
YCCWKDGHGCQGDJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.39072
Rotatable Bonds
10
Heavy Atom Count
41
Polar Areas
64.17
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 57331340
SID: 136333632
ChEMBL ID
CHEMBL3104677
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 202.43 nM
   TI
   LI
   LO
   TS