General Information of the Compound
Compound ID
CP0442338
Compound Name
1-deoxy-1-{2-chloro-6-[N'-(5-phenyl-isoxazole-3-carbonyl)-hydrazino]-9H-purin-9-yl}-N-ethyl-beta-D-ribofuranuronamide
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Structure
Formula
C22H21ClN8O6
Molecular Weight
528.913
Canonical SMILES
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NNC(=O)c3cc(on3)-c3ccccc3)nc(Cl)nc12
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InChI
InChI=1S/C22H21ClN8O6/c1-2-24-20(35)16-14(32)15(33)21(36-16)31-9-25-13-17(26-22(23)27-18(13)31)28-29-19(34)11-8-12(37-30-11)10-6-4-3-5-7-10/h3-9,14-16,21,32-33H,2H2,1H3,(H,24,35)(H,29,34)(H,26,27,28)/t14-,15+,16-,21+/m0/s1
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InChIKey
CAOHGXDSMIBEFC-KGWSRGFLSA-N
Physicochemical Property
logP
0.6469
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
189.55
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
12
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16103171
SID: 24749896
ChEMBL ID
CHEMBL386420
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS