General Information of the Compound
Compound ID
CP0441404
Compound Name
4-nitrobenzyl allyl(1-(((3a'S,4'S,5'S)-5'-phenyltetrahydro-3'H-spiro[cyclohexane-1,2'-pyrrolo[1,2-b]isoxazole]-4'-yl)methyl)piperidin-4-yl)carbamate
    Show/Hide
Structure
Formula
C34H44N4O5
Molecular Weight
588.749
Canonical SMILES
[O-][N+](=O)c1ccc(COC(=O)N(CC=C)C2CCN(C[C@H]3[C@@H]4CC5(CCCCC5)ON4C[C@@H]3c3ccccc3)CC2)cc1
    Show/Hide
InChI
InChI=1S/C34H44N4O5/c1-2-19-36(33(39)42-25-26-11-13-29(14-12-26)38(40)41)28-15-20-35(21-16-28)23-31-30(27-9-5-3-6-10-27)24-37-32(31)22-34(43-37)17-7-4-8-18-34/h2-3,5-6,9-14,28,30-32H,1,4,7-8,15-25H2/t30-,31-,32+/m1/s1
    Show/Hide
InChIKey
BPMDYCAPYKCBNC-IWWXRALLSA-N
Physicochemical Property
logP
6.3062
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
88.39
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44373973
ChEMBL ID
CHEMBL157983
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS