General Information of the Compound
Compound ID
CP0438716
Compound Name
1-[(1S)-1-(1,6-dimethylbenzimidazol-2-yl)-2-[1-(2-methylpropanoyl)piperidin-4-yl]ethyl]-4-(4-phenoxyphenyl)piperazine-2,5-dione
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Structure
Formula
C36H41N5O4
Molecular Weight
607.755
Canonical SMILES
CC(C)C(=O)N1CCC(C[C@H](N2CC(=O)N(CC2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1
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InChI
InChI=1S/C36H41N5O4/c1-24(2)36(44)39-18-16-26(17-19-39)21-32(35-37-30-15-10-25(3)20-31(30)38(35)4)41-23-33(42)40(22-34(41)43)27-11-13-29(14-12-27)45-28-8-6-5-7-9-28/h5-15,20,24,26,32H,16-19,21-23H2,1-4H3/t32-/m0/s1
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InChIKey
PYNSRWPXURAEMH-YTTGMZPUSA-N
Physicochemical Property
logP
5.87522
Rotatable Bonds
8
Heavy Atom Count
45
Polar Areas
87.98
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155538233
ChEMBL ID
CHEMBL4476161
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
IC50 = 859 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15000 nM