General Information of the Compound
Compound ID
CP0437163
Compound Name
(2R,3R,4S,5R)-2-[6-(2-bicyclo[2.2.1]heptanylamino)-2-(3,5-dimethylphenyl)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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Structure
Formula
C30H37N7O3
Molecular Weight
543.672
Canonical SMILES
Cc1cc(C)n(C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(NC4CC5CCC4C5)nc(nc23)-c2cc(C)cc(C)c2)n1
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InChI
InChI=1S/C30H37N7O3/c1-15-7-16(2)9-21(8-15)27-33-28(32-22-12-19-5-6-20(22)11-19)24-29(34-27)36(14-31-24)30-26(39)25(38)23(40-30)13-37-18(4)10-17(3)35-37/h7-10,14,19-20,22-23,25-26,30,38-39H,5-6,11-13H2,1-4H3,(H,32,33,34)/t19?,20?,22?,23-,25-,26-,30-/m1/s1
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InChIKey
DYGLUVUVCNVFNM-JWMPSBNMSA-N
Physicochemical Property
logP
3.84338
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
123.14
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137661322
ChEMBL ID
CHEMBL4097343
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 59.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10500 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 60000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 667 nM
   TI
   LI
   LO
   TS