General Information of the Compound
Compound ID
CP0437016
Compound Name
1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-{1-[3-(3-isopropyl-ureido)-benzyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-urea
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Structure
Formula
C30H33N5O5
Molecular Weight
543.624
Canonical SMILES
CC(C)NC(=O)Nc1cccc(CN2c3ccccc3CCC(NC(=O)Nc3ccc4OCCOc4c3)C2=O)c1
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InChI
InChI=1S/C30H33N5O5/c1-19(2)31-29(37)32-22-8-5-6-20(16-22)18-35-25-9-4-3-7-21(25)10-12-24(28(35)36)34-30(38)33-23-11-13-26-27(17-23)40-15-14-39-26/h3-9,11,13,16-17,19,24H,10,12,14-15,18H2,1-2H3,(H2,31,32,37)(H2,33,34,38)
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InChIKey
MEJPGFAFBJSSIT-UHFFFAOYSA-N
Physicochemical Property
logP
4.6574
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
121.03
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10626335
SID: 15656773
ChEMBL ID
CHEMBL329997
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02259, Neuropeptide Y receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 18 nM
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   LI
   LO
   TS