General Information of the Compound
Compound ID
CP0434964
Compound Name
17beta-Hydroxy-11beta-[4-(10-methoxycarbonyl-N-methyldecylamino)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C40H55NO4
Molecular Weight
613.883
Canonical SMILES
COC(=O)CCCCCCCCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C40H55NO4/c1-5-24-40(44)25-23-36-34-21-17-30-27-32(42)20-22-33(30)38(34)35(28-39(36,40)2)29-15-18-31(19-16-29)41(3)26-13-11-9-7-6-8-10-12-14-37(43)45-4/h15-16,18-19,27,34-36,44H,6-14,17,20-23,25-26,28H2,1-4H3/t34-,35+,36-,39-,40-/m0/s1
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InChIKey
GYKUKNLUPOUXOK-MJIFNDCGSA-N
Physicochemical Property
logP
8.4606
Rotatable Bonds
13
Heavy Atom Count
45
Polar Areas
66.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231634
SID: 57583583
ChEMBL ID
CHEMBL450052
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 0.63 nM
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